The acute association between interpersonal violence, alcohol and drug use, self-harm, and mental health issues is relatively unexplored. Violence-related ambulance attendances were analysed, differentiated by type of violence and by victim or aggressor of violence, as well as the co-occurrence of alcohol and drug use, self-harm, and mental health issues. Ambulance attendances related to victims of violence had few co-occurring issues beyond alcohol and drug misuse. In contrast, attendances related to aggressors were more complex, with high proportions of co-occurring mental health, self-harm, and alcohol and drug issues. These findings demonstrate the utility of ambulance data for surveillance of interpersonal violence.